Histopathological characteristics of pulmonary emphysema in experimental model

1 Universidade de São Paulo, São Paulo, SP, Brazil. Corresponding author: Antonio Di Petta − Rua Rodolfo Marcos Teófilo, 49 − Freguesia do Ó – Zip code: 02862-100 − São Paulo, SP, Brazil − Phone: (55 11) 3851-0028 − E-mail: [email protected] Received on: Nov 6, 2012 – Accepted on: Dec 2, 2013 DOI: 10.1590/S1679-45082014AI2681 Historically pulmonary emphysema was described in 1834 by Laennec on the basis of observations made on the cut surface of postmortem human lungs being the lesion attributed to the atrophy of lung tissue from pulmonary hyperinflation.(1) Hence, emphysema was redefined as a “abnormal and permanent dilation of Figure 1. Photomicrographs of lung parenchyma (hematoxylin-eosin) x 100 increased. (A) Naïve lung and (B) emphysematous lung showing hyperdistension of alveolar ducts associated with the rupture of alveolar septa A B